Silagra Dosage: How to take Silagra
Generic name: Sildenafil.
Dosage: Silagra 100mg.
Category: Erectile Dysfunction, Viagra.
Buy Silagra online without prescription: Silagra Online Pharmacy
How to take Silagra
For most patients, the recommended dose is 50 mg; the medication should be taken as needed approximately 1 hour before sexual activity. Depending on effectiveness and tolerability, the dose may be increased to 100 mg or decreased to 25 mg.
The main active ingredient of Silagra is Sildenafil. Sildenafil affects the response to sexual stimulation by increasing smooth muscle relaxation through nitric oxide, a chemical that is normally released during sexual stimulation. This relaxation of smooth muscles helps increase blood flow to certain areas of the penis, resulting in an erection.
Sildenafil is prescribed for the treatment of erectile dysfunction (impotence) in men and pulmonary arterial hypertension.
Eating foods high in fat may delay the effects of this drug. Avoid drinking grapefruit or grapefruit juice while taking Sildenafil.
Precautionary measures
Before you start taking sildenafil, tell your doctor or pharmacist if you are allergic to it or have any other allergies. Older people may be more susceptible to the side effects of the drug.
Contraindications
Silagra is contraindicated in patients who are taking other medications for impotence or who are using nitrate medications for chest pain or heart problems.
This medicine should not be taken by women, children, or anyone with a known hypersensitivity to any component of the tablet.
After oral administration, sildenafil is rapidly absorbed. The maximum plasma concentration of sildenafil (Cmax) is achieved within 30–120 minutes (average 60 minutes) after oral administration on an empty stomach. The average absolute bioavailability after oral administration of the drug is 40%. Following oral administration of sildenafil in the recommended dose range (25–100 mg), the area under the pharmacokinetic curve (AUC) and Cmax values increase in direct proportion to the dose taken.
When Silagra is taken with food, the rate of absorption is reduced with an average delay in time to maximum plasma concentration (tmax) of 60 minutes and an average decrease in Cmax of 30%.
After oral administration of Silagra in a single dose of 100 mg, the average maximum total plasma concentration of sildenafil is approximately 440 ng/ml (with a coefficient of variation of 40%). Due to the fact that sildenafil is 96% bound to plasma proteins, the average maximum concentration of free sildenafil in blood plasma is 18 ng/ml (38 nM). Protein binding is independent of the total drug concentration.
In healthy volunteers who received a single dose of sildenafil 100 mg, less than 0.0002% of the dose was found in the ejaculate 90 minutes after taking the dose.
The terminal half-life of Sildenafil is 3 to 5 hours.
Silagra dosage
Silagra can be taken regardless of meals. However, if you take Viagra with food, the pill may take longer to work.
The recommended dose of Silagra is 50 mg orally approximately 1 hour before sexual intercourse. Considering the effectiveness and tolerability, the dose can be increased to 100 mg. The maximum recommended dose is 100 mg.
The tablet must be swallowed whole with a glass of water. The maximum recommended frequency of use is 1 time per day.
In elderly patients (≥ 65 years), no dose adjustment is required. For mild to moderate renal failure (creatinine clearance 30–80 ml/min), no dose adjustment is required. Due to the fact that the clearance of sildenafil is reduced in patients with impaired liver function (for example, cirrhosis), the use of the drug at a dose of 25 mg should be considered. Considering the effectiveness and tolerability of the drug, if necessary, its dose can be gradually increased to Silagra 50 mg and 100 mg.
Side Effects
- Nervous System: Headache
- Cardiovascular System: Vasodilation (flushing)
- Visual System: Changes in vision (blurred vision, sensitivity to light) Chromatopsia (mild and transient, mainly altering color perception)
- Respiratory System: Rhinitis (nasal congestion)
- Digestive System: Dyspepsia
- General state disturbances: reactions of increased sensitivity (including skin rash)
- Changes in the central and peripheral nervous systems: seizures
- Changes in the cardiovascular system: tachycardia, low blood pressure, fainting, nosebleeds
- Gastrointestinal disorders: vomiting Changes in the visual system: eye pain, redness of the eyes/conjunctival injection
- Reproductive system disorders: prolonged erection and/or priapism.
Overdose
With a single dose of the drug up to 800 mg, adverse events were comparable to those with sildenafil at lower doses but occurred more frequently. Treatment: symptomatic therapy. Hemodialysis does not accelerate sildenafil clearance because it is actively bound to plasma proteins and not excreted in the urine.
Drug interaction
Silagra (Sildenafil) may interact with certain medications, potentially altering their effects or increasing the risk of side effects. It is crucial to inform your doctor about all medications you are currently taking, including prescription, over-the-counter, herbal supplements, and vitamins, to avoid potential interactions. Below are some notable drug interactions with Silagra:
- Nitrates: Concurrent use of Silagra with nitrates (such as nitroglycerin) or nitric oxide donors (such as amyl nitrite) is contraindicated. Combining these medications can lead to a severe decrease in blood pressure, which may result in dizziness, fainting, or even a heart attack.
- Alpha-Blockers: Caution is advised when Silagra is used concomitantly with alpha-blockers (such as doxazosin, tamsulosin) as both medications can lower blood pressure. This combination may lead to symptomatic hypotension, especially in elderly patients or those with pre-existing cardiovascular conditions.
- Antihypertensive Agents: Silagra can potentiate the hypotensive effects of antihypertensive drugs. Close monitoring of blood pressure is recommended when using these medications together.
- Protease Inhibitors: Protease inhibitors (such as ritonavir, saquinavir) used in the treatment of HIV/AIDS can increase plasma concentrations of Silagra. This may heighten the risk of sildenafil-related adverse effects. Dose adjustments may be necessary when these medications are co-administered.
- CYP3A4 Inhibitors: Drugs that inhibit the CYP3A4 enzyme (such as ketoconazole, erythromycin, clarithromycin) can increase sildenafil plasma concentrations. This may potentiate the pharmacological effects and side effects of Silagra. Dose adjustments may be required when these medications are used together.
- CYP3A4 Inducers: CYP3A4 inducers (such as rifampicin, phenytoin, carbamazepine) can decrease sildenafil plasma concentrations, potentially reducing its efficacy. Close monitoring of therapeutic effects is advised, and dosage adjustments may be necessary.
- Grapefruit Juice: Grapefruit juice may increase sildenafil plasma concentrations by inhibiting CYP3A4 metabolism. Avoid consuming grapefruit or grapefruit juice while taking Silagra to minimize the risk of interactions.
It is essential to consult with a healthcare professional for personalized advice regarding potential drug interactions before starting Silagra or any other medication.
