Coumadin (Warfarin)
Generic name: Warfarin.
Dosage: Coumadin 1mg, 2mg, 5mg.
Category: Cardiovascular.
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Coumadin – recommendations for use and dosage
This medication suppresses effects of vitamin K, which actively participates in clotting of the blood. It results in prevention of blood clot formation. Blood clots may form in different parts of body such as in vessels of extremities after periods of immobility, in vessels of lungs, around artificial heart valves causing embolism and shortness of breath, chest pain depending on the place where they block a vessel. Coumadin is used for treatment of patients with blood clots in the lower extremities, pulmonary embolism, atrial fibrillation, in certain orthopedic surgeries such as knee or hip replacements, myocardial infraction.
Dosage and direction
Never take a double dose of Coumadin. It maybe taken with or without food. Patients with liver or kidney dysfunction should take lower doses of the medication.
Precautions
Avoid eating cranberries or any cranberry herbal products, drinking alcohol and sports or activities that can result in bruising. If you need to do a lumbar puncture or any kind of surgery inform your doctor about taking Coumadin.
Contraindications
Acute bleeding, liver or kidney failure, acute arterial hypertension, pregnancy.
Possible side effect
Bleeding, necrosis of skin are among most dangerous ones. Black tarry stools, digestion disorders, nasal or gum bleeding, abundant and persisting menstrual discharge, unreasonable bruises, hair loss.
Drug interaction
Warfarin, as an anticoagulant, may interact with various medications, including those that may increase its effect or decrease its effectiveness. Here are some examples of drugs and substances that may interact with warfarin:
- Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, diclofenac and some others, may increase the risk of bleeding when taken with warfarin.
- Antibiotics such as amoxicillin, azithromycin, ciprofloxacin and others can change the metabolism of warfarin and increase its concentration in the body.
- Antifungal drugs such as fluconazole, ketoconazole and others may also increase the concentration of warfarin in the blood.
- Medicines containing vitamin K, such as some vitamin supplements or fat-soluble vitamins, may reduce the effectiveness of warfarin.
- Drugs that affect liver function, such as some antibiotics or antifungals, may increase the effect of warfarin, since the liver plays a key role in its metabolism.
It is important to discuss all medications, including herbal drugs and food supplements, with your doctor or pharmacist before starting warfarin treatment to avoid unwanted interactions.
Missed dose
If you missed a dose take it as soon as you remember, but not if it is almost time of the next intake by your schedule. If it occurred do not take the missed dose and simply return to your regular schedule. Do not try to compensate a missed dose by taking an extra one. Never take a double dose of Coumadin.
Overdose
If you suspect that you took too much of the medication you may observe excessive bleeding from cuts or wounds, blood in the urine or stools, and heavy menstrual periods in women. Look for immediate medical help in such cases.
Storage
Store at room temperature in a dark dry place.
Disclaimer
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
