Buy Brand Cialis
Generic name: Tadalafil.
Dosage: Brand Cialis 20mg, 40mg, 5mg, 10mg.
Category: Erectile Dysfunction,Cialis.
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Brand Cialis – recommendations for use and dosage
The first-choice medications for patients suffering from erectile dysfunction are phosphodiesterase type 5 inhibitors, such as Brand Cialis. Brand Cialis, which has been successfully used to treat erectile dysfunction on demand, can be used continuously once a day for months or even years, according to the study.
The use of tadalafil significantly improves erectile dysfunction, and the side effects of taking the medication are comparable to those of taking a placebo. Erectile dysfunction can also be an early sign of atherosclerosis and coronary artery disease. This link between the development of erectile dysfunction and the presence of concomitant diseases is due to a single mechanism: impairment of vascular endothelium.
Microangiopathies lead to dysregulation of the nitric oxide (NO) system. NO, produced in nerve endings and endothelial cells during sexual arousal, activates the guanylate cyclase system, leading to an increase in cyclic guanosine monophosphate (cGMP) concentration. cGMP activates a specific protein kinase, causing a decrease in calcium concentration inside the cell and relaxation of smooth muscle cells in the arteries, resulting in increased blood flow to the corpus cavernosum and the onset of an erection.
In the cavernous tissue, under the action of the specific phosphodiesterase type 5 (PDE-5), cGMP is converted into inactive 5′-guanosine monophosphate. With insufficient NO production by ischemic or damaged endothelium, cGMP concentration in vascular smooth muscle cells decreases, so there is no increase in blood flow to the corpus cavernosum, and an effective erection does not occur. However, tissue cGMP concentration is regulated both by the rate of synthesis and by the rate of degradation under the influence of PDE-5. Inhibition of cGMP degradation by phosphodiesterase type 5 inhibitors leads to an increase in its concentration in smooth muscle cells, promoting erection. Originally developed as nitrovasodilators for the treatment of coronary artery disease, PDE5 inhibitors have demonstrated a high specificity for the vascular endothelium of the cavernous tissue.
Most doctors initiate treatment for erectile dysfunction by prescribing PDE-5 inhibitors. The half-life of sildenafil and vardenafil is 4 hours, while that of tadalafil is 17.5 hours. Tadalafil’s steady-state concentration is reached on the 5th day with daily administration and is 1.6 times higher than the initial concentration, so the drug does not accumulate, allowing for continuous use.
Recently, several studies have been conducted proving that continuous use of tadalafil helps maintain erectile function. In most men over 50 with erectile dysfunction, the most common condition is benign prostatic hyperplasia (BPH), which is associated with lower urinary tract symptoms (LUTS), such as frequent urination, abdominal strain during urination, incomplete bladder emptying, and low urinary flow rate.
Can Cialis be taken every day?
Cialis, which has been successfully used to treat erectile dysfunction on demand, can also be used continuously once daily for months or even years at a dosage of Cialis 5 mg for prostate issues.
The advantages of Generic Cialis include sufficient effectiveness, the possibility of its combination with nitrates, almost total absence of side effects and systemic negative effects, and the relatively low cost of the medication.
Cialis is available in different dosage forms
- Pills – this release form is similar to the original Cialis. However, the dose of tadalafil can be 5, 10, 20 mg.
- Chewable tablets – they are not swallowed with water but dissolved or chewed. Such medications start to be absorbed instantly, so the effect is slightly faster. Cialis chewable tablets are called Cialis Soft.
- Gels – they are packaged in disposable sachets, the tadalafil content can be 10 and 20 mg. The product has a pleasant fruity taste and does not need to be drunk with water. After administration, absorption occurs instantly, and the effect of the Cialis Jelly appears after 10 minutes. Despite the pleasant taste and ease of use, it is not recommended to use more than one Cialis Jelly sachet per day, as it will not affect the quality of the erection. However, this can lead to increased side effects.
- Capsules – Cialis Super Active, this is a gel-like substance enclosed in a thin shell. The drug is intended for oral use. Gastric juice enzymes instantly dissolve the membrane, and the gel begins to be absorbed immediately. The effect appears quickly after 5-10 minutes. The medication has an instant effect, and the result also lasts for 36 hours.
